Thesis (Ph.D.) - University of Birmingham, Dept of Biochemistry.
|Statement||by Patricia A. James.|
In addition to regulation at the transcriptional level, GCK is also regulated in the liver at the post-transcriptional level by glucokinase regulatory protein (GCKR),. GCKR is primarily expressed in the liver , , and possibly the brain , with little if any expression in pancreatic beta-cells , .Cited by: Hepatic glucokinase activity in the C3H/He strain of mice is about twice that in the C58 strain. Genetic analysis of hybrids and back-crosses indicates control of activity by a single codominant gene. The adaptations of activity that occur when animals of the two strains are starved, fed a carbohydrate-free diet or made streptozotocin-diabetic are similar in the two by: 6. A recent study revealed that hepatic glucokinase overexpression in the liver of chow-fed C57BL/6 mice suppresses sympathetic nerve activity to BAT, thereby downregulating the expression of the thermogenesis-related Ucp1, Pgc1a, and Dio2 genes and modulating predisposition to sely, hepatic glucokinase knockdown in high-fat diet (HFD)-fed C57BL/6 mice attenuated Cited by: 4. The role of insulin, glucocorticoids, and hepatic cyclic AMP in the regulation of the activity of rat liver glucokinase was investigated in following results were found: (i) Refeeding of starved rats with glucose or injection of diabetic animals with insulin resulted in a dramatic increase in the concentration of serum insulin and a decrease in the concentration of hepatic cyclic AMP Cited by:
Liver glucose metabolism is dependent on glucokinase activity. Glucokinase expression is transcriptionally regulated by hormones and metabolites of glucose, and glucokinase activity is dependent on reversible binding of glucokinase to a specific inhibitor protein, glucokinase regulatory protein (GKRP), and to other binding proteins such as 6-phosphofructokinase/fructose 2,6-bisphosphatase Cited by: As glucagon’s opponent, insulin stimulates glycolysis via enhanced expression of the hepatic glucokinase gene, 14, 15 a key enzyme that converts glucose into by: The balance of catabolic and anabolic glucose fluxes in the liver is crucial for glucose homeostasis and is disturbed in diabetes mellitus. In this Review, the authors discuss progress in our Cited by: Hepatic GCK mRNA expression is associated with triglyceride content in human liver biopsies (r = , P = ). Furthermore, hepatic GCK mRNA expression is associated with lipogenic gene expression (fatty acid synthase, r = , P = ; acetyl-coenzyme A carboxylase-α, r = , P = , and acetyl-coenzyme A carboxylase-β, r = , P = ) and the de novo lipogenesis Cited by:
Abstract. A simple method for isolation of glucokinase from a soluble fraction of rat liver was proposed, making it possible to obtain the enzyme preparation characterized by high specific activity, native cooperative characteristics of the enzyme, and actually complete absence of other molecular forms of Author: L. Ya. Khu, N. Yu. Goncharova, A. M. Rubtsov. Citation: Lu M, Li P, Bandyopadhyay G, Lagakos W, DeWolf WE Jr, et al. () Characterization of a Novel Glucokinase Activator in Rat and Mouse Models. PLoS PLoS ONE 9(2): e doi The glycolytic pathway is initiated by a hexokinase that converts glucose to glucosephosphate in the cells. Glucokinase, the rate-limiting enzyme of the glucose oxidation reaction, which acts. THE JOURNAL OF BIOLOGICAL CHEMISTRY Vol. , No. 13, Issue of July , Printed in U.S.A. Studies on the Mechanism by Which Exogenous into Liver Glycogen in the Rat A DIRECT OR AN INDIRECT PATHWAY?* Glucose Is Converted (Received for publication, Decem ) Christopher B. Newgard, Laurence J. Hirsch, Daniel W. Foster, and J. Denis McGarryS.